Intravenous NAC for drug overdose

Glutathione is an endogenous antioxidant and has a wide role in many of the body's defenses. Treatment with N-acetylcysteine (NAC) has been shown to increase levels of glutathione. Intravenous NAC is used in hospitals to protect against acetaminophen toxicity. Oral forms of this nutrient are available over the counter as dietary supplements.

Risks, dangers, caution with intravenous NAC therapy
Possible reactions to intravenous N acetyl cysteine use include anaphylaxis, rash, pruritus, angioedema, and bronchospasm. Histamine seems to be an important mediator of the allergic response. Females and those with a history of asthma or atopy are particularly susceptible to the allergic or anaphylactic side effects of intravenous NAC use. Most anaphylactic reactions occur at the start of acetylcysteine treatment when concentrations are highest. Acetylcysteine also affects clotting factor activity.

Use in children with liver failure
Intravenous NAC is a well-tolerated and a safe medication for pediatric patients with acute liver failure,